Anti -Nanos3 Rabbit pAb

價格：在線咨詢

貨號：

KT011806

產品規(guī)格：

100 μL

Applications：

Species：

M/R

品牌：

萬物

購買數量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	Nanos3 rabbit polyclonal antibody
Protein full name	Nanos homolog 3
Synonyms	NOS-3, Nanos3, Nos3, Nanos C2HC-Type Zinc Finger 3, ZC2HC12C, NANOS1L
Immunogen	Recombinantproteincorrespondingto Mouse Nanos3
Isotype	IgG
Purity	Affinity purification
Predicted MW.	19 kDa
Observed MW.	19 kDa
Uniprot ID	P60324

Applications

Applications	Species	Dilution	Positive Sample
WB	Mouse, Rat	1: 500-1: 1000	testis, kidney, brain

Background

Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.

Images

Western blot analysis of Nanos3 (GB111666) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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